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ConclusionsĪmong previously untreated patients with metastatic melanoma, nivolumab alone or combined with ipilimumab resulted in significantly longer progression-free survival than ipilimumab alone. Treatment-related adverse events of grade 3 or 4 occurred in 16.3% of the patients in the nivolumab group, 55.0% of those in the nivolumab-plus-ipilimumab group, and 27.3% of those in the ipilimumab group. In patients with tumors positive for the PD-1 ligand (PD-L1), the median progression-free survival was 14.0 months in the nivolumab-plus-ipilimumab group and in the nivolumab group, but in patients with PD-L1–negative tumors, progression-free survival was longer with the combination therapy than with nivolumab alone (11.2 months vs.
#School mate 2 3p plus#
The median progression-free survival was 11.5 months (95% confidence interval, 8.9 to 16.7) with nivolumab plus ipilimumab, as compared with 2.9 months (95% CI, 2.8 to 3.4) with ipilimumab (hazard ratio for death or disease progression, 0.42 99.5% CI, 0.31 to 0.57 P<0.001), and 6.9 months (95% CI, 4.3 to 9.5) with nivolumab (hazard ratio for the comparison with ipilimumab, 0.57 99.5% CI, 0.43 to 0.76 P<0.001). Results regarding progression-free survival are presented here. Progression-free survival and overall survival were coprimary end points. We assigned, in a 1:1:1 ratio, 945 previously untreated patients with unresectable stage III or IV melanoma to nivolumab alone, nivolumab plus ipilimumab, or ipilimumab alone. In this randomized, double-blind, phase 3 study, nivolumab alone or nivolumab plus ipilimumab was compared with ipilimumab alone in patients with metastatic melanoma. Nivolumab (a programmed death 1 checkpoint inhibitor) and ipilimumab (a cytotoxic T-lymphocyte–associated antigen 4 checkpoint inhibitor) have been shown to have complementary activity in metastatic melanoma. The most trusted, influential source of new medical knowledge and clinical best practices in the world.
#School mate 2 3p license#
Information and tools for librarians about site license offerings. Valuable tools for building a rewarding career in health care. The authorized source of trusted medical research and education for the Chinese-language medical community. The most advanced way to teach, practice, and assess clinical reasoning skills. Information, resources, and support needed to approach rotations - and life as a resident. The most effective and engaging way for clinicians to learn, improve their practice, and prepare for board exams. NEW! Peer-reviewed journal featuring in-depth articles to accelerate the transformation of health care delivery.Ĭoncise summaries and expert physician commentary that busy clinicians need to enhance patient care.
#School mate 2 3p trial#
Removing the guard 21.? (after 21.NEW! A digital journal for innovative original research and fresh, bold ideas in clinical trial design and clinical decision-making. (A30) English, Symmetrical, 30 moves, 0-1 (D56) Queen's Gambit Declined, 41 moves, 1-0 (D30) Queen's Gambit Declined, 26 moves, 1-0 (A07) King's Indian Attack, 21 moves, 0-1 (A01) Nimzovich-Larsen Attack, 31 moves, 0-1 (C81) Ruy Lopez, Open, Howell Attack, 23 moves, 1-0 (D14) Queen's Gambit Declined Slav, Exchange Variation, 27 moves, 1-0 (C34) King's Gambit Accepted, 10 moves, 1-0 (D06) Queen's Gambit Declined, 8 moves, 1-0 (C69) Ruy Lopez, Exchange, Gligoric Variation, 70 moves, 1-0 (C35) King's Gambit Accepted, Cunningham, 8 moves, 0-1
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Overburdened Defender Epaulette Mate 23.? (C40) King's Knight Opening, 17 moves, 0-1 (C36) King's Gambit Accepted, Abbazia Defense, 12 moves, 0-1 (C32) King's Gambit Declined, Falkbeer Counter Gambit, 11 moves, 1-0 (C69) Ruy Lopez, Exchange, Gligoric Variation, 12 moves, 0-1 (E34) Nimzo-Indian, Classical, Noa Variation, 34 moves, 1-0 (D52) Queen's Gambit Declined, 12 moves, 1-0 (A29) English, Four Knights, Kingside Fianchetto, 31 moves, 1-0 (D37) Queen's Gambit Declined, 23 moves, 1-0 (C30) King's Gambit Declined, 16 moves, 0-1 (B81) Sicilian, Scheveningen, Keres Attack, 62 moves, 0-1Īfter 20 moves, space count is White 17, Black 2 These are Puzzles of the Day, mostly Mondays but a few Tuesdays, that I think can be discussed with elementary school children who are still learning the basics.